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title[alternative]contributor[author]contributor[department]date[issued] citationsidentifier[issn]abstractkeywordsidentifier[uri]\Clinicopathologic Characteristics and Prognosis of Triple Negative Early-Stage Breast CancerHŬ2008-12R L1 )T@ Ť¸\ ©ƴ@ \L` ©ƴ L1tt ٳ HER2ĳ L1<\ )T<\ X, ĳ x )T Dt @ X ĳ@ \ | д <\ L$8 . L1 )TX ѼYx 1@ X̸ )X | XՔpĳ ɔX. t Ȑǔ p0 Ѽ0 XՔ L1 )TX ѼY D LD0 t l| X. 1995D0 2005DL ĬYP ٳX̸ @ X p0 Ѽ0X )T<\ 821D <\ X X40]D <\ ֥<\ pȬ| X. Xǔ L1 )Tp D L1 )Tp<\ t, ), ȑX l0, t 4, Ѽ0, u , pY , p mT TYՔƕ, `, t(D DPX. 821X X 200t L1 )T<\ , t DP 358 tXX D(t L1p ιX<ǘ Ĭ X1@ . ȑX l0 2 cm p ȑt L1p Ĭ<\ XXՌ T<ǘ(p = 0.042), t 4 DP P p (t| t JX. pY u DP L1p 3 x Ĭ<\ XXՌ T(p = 0.000). 2007DL ȴ XX Y 0@ 50 t, m l t 50, t 98t, ݹ@ 65 X. L1p @ m `(n = 21, 10.5%) ݹ`(n = 25, 12.8%)D (p = 0.006, p = 0.010). t l D L1p Dt L1@ \ ѼY | Ux ` , L1 )TX X̸ 0 8\ X DՔ` <\ p, x 0 l DՔ` <\ .;
Triple negative breast cancer (estrogen receptor-negative, progesterone receptor-negative, and HER2-negative) is associated with high risk of recurrence and poor prognosis. We investigated the characteristics and prognosis of triple negative early-stage breast cancer. We reviewed the records of 821 early-stage breast cancer patients who treated at our hospital from 1995 to 2005. We studied difference between triple negative group compared with non triple negative group. Of 821 early-stage breast cancer patients, 200 were classified as triple negative. Histologic and nuclear grade of triple negative group were significantly higher than those of non triple negative group (p = 0.000). Large tumors (> 2 cm) in triple negative group were significantly more than those in non triple negative group (p = 0.042). As of May 2007, with a median follow-up time of 50 months, there have been 50 local recurrences, 98 distant metastases, and 65 deaths. There were significant high rates of local recurrence (n = 21, 10.5%) and death (n = 25, 12.8%) in triple negative group (p = 0.006, p = 0.010 respectively). Patients classified as triple negative breast cancer have poor pathologic findings and prognoses. Careful treatment and follow-up are important to triple negative early-stage breast cancer and further investigation is necessary to triple negative breast cancer.;4http://kumel.medlib.dsmc.or.kr/handle/2015.oak/11738z3:\k'
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