투석개시 환자에서 대동맥활 석회화와 관련된 임상지표 탐색

Abstract

Cardiovascular disease is common in patients with end-stage kidney disease and it is the most important cause of death in these patients. Aortic calcification has been recognized as an important risk factor for cardiovascular disease in dialysis patients. The aim of this study was to evaluate the aortic arch calcification (AoAC) using chest radiography and to examine the association of clinical and biochemical parameters and aortic arch calcification in new dialysis patients. A total of 29 patients were enrolled in this study and their medical records including chest radiography were reviewed retrospectively. AoAC was semiquantitatively estimated with an AoAC score on plain chest radiography. Initial AoAC was 6.9 ± 11.7% and it was increased to 11.2 ± 11.7%, two year after dialysis. Age and serum inorganic phosphorus concentration were significantly associated with AoAC, whereas other biochemical parameters including fibroblast growth factor-23, had no association with AoAC. In conclusion, an association between serum inorganic phosphorus level and AoAC exists in end-stage kidney disease patients. Control of hyperphosphatemia with dietary phosphorus restriction should be focused for the prevention of aortic arch calcification in these patients.