폐의 선암종, 편평세포암종 및 과오종에서 현미부수체 불안정성에 대한 비교

Other Titles
Comparison of Microsatellite Instability in Adenocarcinoma, Squamous Cell Carcinoma and Hamartoma of Lungs
Authors
이덕헌
Issue Date
2012-12
Awarded Date
2013
Abstract
폐종양의 형성에 어떤 종류의 유전적 불안정성이 중요한 역할을 하는지 조사하기 위하여 핵과 사립체의 현미부수체 불안정성(nuclear microsatellite instability(nMSI), mitochondrial microsatellite instability(mtMSI)), 그리고 사립체 DNA 복제수(mitochondrial DNA copy number, mtCN)를 48예의 선암종, 42예의 편평세포암종 및 21예의 과오종으로 연구하였다. nMSI는 선암종에서 4.2%(2/48), 편평세포암종에서 14.3%(6/42), 그리고 과오종에서 23.8%(5/21)로 각각 검출되었고, 선암종과 과오종 사이에서 nMSI의 빈도는 유의한 차이가 나타났다. mtMSI는 선암종에서 20.8%(10/48), 편평세포암종에서 19%(8/42), 그리고 과오종에서 9.5%(2/21)로 검출되었다. 과오종에서는 mtMSI와 종양의 크기에 유의한 차이가 있었다. mtCN가 증가된 빈도와 mtCN의 평균값은 선암종에서 72.9%(35/48)와 5.05 ± 8.17, 편평세포암종에서 71.4%(30/42)와 3.34 ± 5.14, 그리고 과오종에서 57.1%(12/21)와 1.53 ± 1.36로 각각 나타났다. mtCN가 증가된 빈도와 mtCN의 평균값은 과오종이 선암종과 편평세포암종보다 유의하게 낮게 나타났다. 선암종에서 mtCN의 감소와 전이된 림프절 수 사이에서 유의성이 관찰되었다. nMSI와 mtMSI 사이에서의 연관관계는 오직 편평세포암종에서만 발견되었다. 이 연구에서 nMSI는 과오종에서, 그리고 mtMSI와 mtCN는 선암종과 편평세포암종에서 중요한 역할을 할 것으로 추정된다.
I conducted an analysis of nuclear microsatellite instability (nMSI), mitochondrial microsatellite instability (mtMSI), and mitochondrial DNA copy number (mtCN) in order to investigate what kind of genetic instability plays important roles in lung tumoriogenesis in 111 cases of lung tumors, including 48 adenocarcinomas (AD), 42 squamous cell carcinomas (SCC), and 21 hamartomas (HM). nMSI was detected in 4.2% (2/48) of AD, 14.3% (6/42) of SCC, and 23.8% (5/21) of HM, respectively. A significant difference in the frequency of nMSI was observed between AD and HM. mtMSI was detected in 20.8% (10/48) of AD, 19% (8/42) of SCC, and 9.5% (2/21) of HM, respectively. A significant correlation was observed between mtMSI and tumor size in HM. mtCN was increased in 72.9% (35/48) of AD, 71.4% (30/42) of SCC, and 57.1% (12/21) of HM, respectively. The mean value of mtCN was 5.05 ± 8.17 in AD, 3.34 ± 5.14 in SCC, and 1.53 ± 1.36 in HM, respectively. The frequency of increased mtCN and mean value of mtCN in HM were significantly lower than those in malignant tumors. In AD, a significant correlation was observed between mtCN and metastatic lymph nodes. The mean number of metastatic lymph nodes was greater in cases with decreased mtCN than in those with increased mtCN. A positive relationship was observed between nMSI and mtMSI in SCC. Results of this study suggest that the role of nMSI is more important than that of mtMSI in development of HM, whereas mtMSI and mtCN play a more important role in development of AD and SCC.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/11502
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3. 학위논문 > 1. School of Medicine (의과대학) > 박사
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