식이성 지방의 함량과 종류가 흰쥐 Lipoprotein의 분획상에 미치는 영향

Abstract

Effect of a high level and types of dietary fat on serum lipoproteins was investigated in Sprague-Dawley rats weighing 60-65gm. The animals were divided into three groups and were fed 3 different fat diet: 12% calorie fat diet, 45% calorie-butter fat diet, and 45% calorie-corn oil diet. The diets were isoenergetic (4.4Kcal/gm), and were fed to the rats ad libitum for 12 weeks. Mean serum lipoprotein levels in mg/dl for the control group were 36.4±10.7: chylomicron, 15.9±5.2: VLDL, 26.2±4.7: LDL, and 93.3±18.7: HDL. The high corn oil diet did not significantly change the levels of serum lipoproteins except 1.5-fold increase in LDL. However, the high-butter fat diet showed 1.5-to 2-fold increase in serum levels of chylomicron. VLDL and LDL, but no change in HDL level. These result indicate that long-term feeding fo high-fat diet composed of primarily saturated fatty acid increases serum levels of lower dinsity fractions of lipoprotein.