간경변증 환자의 혈청 High Density Lipprotein 분획중 각종 지질과 Apoprotein의 변동

Abstract

Levels of high density lipoprotein (HDL) cholesterol, HDL-triglycerides and HDL-phospholipids were determined after elimination of low density and very low density lipoproteins by sodium phoshotungstate-Mg precipitation procedure in patients with liver cirrhosis. Free cholesterol and individual cholesteryl esters in HDL fractions were measured by high pressure liquid chromatographic method. For analysis of apoproteins, HDL fractions were obtained through ultracentrifugation and apoproteins were analyzed by high pressure liquid chromatography with gel permeation column.

Concentrations of HDL-cholesterol and HDL-triglycerides in patients with liver cirrhosis were significantly decreased compared with those of controls, while HDLᅳphospholipids showed no significant differences. Free cholesterol per total cholesterol ratios in HDL fraction of patients with liver cirrhosis were significantly raised, while cholesteryl linoleate per cholesteryl oleate ratios in HDL fractions were significantly lower than those of control subjects. Apoprotein A- I in HDL fractions was decreased in patients with liver cirrhosis, while apoprotein A-fl showed unremarkable change.