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근이영양증 근세포의 미세형태학적 변화

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Affiliated Author(s)
김덕영
Alternative Author(s)
Kim, Deok Young
Journal Title
Keimyung Medical Journal
Issued Date
1985
Abstract
The author studied two cases of Duchenne type of muscular dystrophy by light and electron microscope to examine the morphologic interpretation about morphologic change and pathogenesis of them.

The results obtained were as follow:

Light microscopically,decrease of muscle fibers, increase of connective tissue, irregularity and rarefaction of muscle of muscle fibers, hyaline degeneration were observed. Histologic findings were markedly variable from nearly normal to markedly affected foci showing severe destruction of muscle fibers and muscle fibers and stromal fatty infiltration.

Electron microscopically, there were focal loss of myofibrils around Z-line which is replaced by mitochondria, dilated SR and lipid droplets on the minimally affected foci. But severely affected portion shows widespread fragmentation of muscle fibers and focal rarefaction of muscle fibers. Rarefaction was especially prominent just beneath sarcolemma. Rarefacted area which composed of granular substance and degenerated membranous tissue was especially prominent just beneath sarcolemma.

Considering the variable rarefaction of muscle fibers which is more prominent beneath degenerated sarcolemma, degeneration of sarcolemma was supposed to be involved on the pathogenesis of muscular dystrophy. And it is reasonable to interpret clinical findings of various muscular

dystrophy according to the theory about degeiieration of sarcolemma. But this study is indirect one and requires further studies about abnomalities of sarcolemma by direct method.
Alternative Title
Ultrastructural Changes of Muscular Dystrophy
Department
Dept. of Plastic Surgery (성형외과학)
Publisher
Keimyung University School of Medicine
Citation
김덕영 and 손태중. (1985). 근이영양증 근세포의 미세형태학적 변화. Keimyung Medical Journal, 4(2), 143–150.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/14388
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 1985
1. School of Medicine (의과대학) > Dept. of Plastic Surgery (성형외과학)
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