B형 간염을 동반한 중증 재생불량성 빈혈 1례

Abstract

Hematolgic changes in viral hepatitis are variable. Moderate anemia, low reticulocyte count, shortened red cell survival, macrocytosis, megaloblastic changes, leukopenia, atypical lymphocytosis and moderate thrombocytopenia are frequently observed, and hemolytic anemia, agranulocytosis and transient pancytopenia are rarely observed. But aplastic anemia caused by viral hepatitis is extremely rare. Most cases of aplastic anemia are caused by non-A, non-B agents and grave prognosis. Bone marrow transplantation from histᄋcompatible donors seems to be the treatment of choice.

Recently we experienced 1 case of severe aplastic anemia probably caused by hepatitis B and treated with anti-lymphocyte globulin (ALG) and high-dose methylprednis이one.