간장 및 비장손상에서 국소지혈제로써의 인체양막의 이용에 대한 실험적 연구

Other Titles
An Experimental Study of Human Amniotic Membrane as a Topical Hemostatic in Canine Liver and Splenic Injury
Authors
손수상김인호강중신
Department
Dept. of Surgery (외과학)
Issue Date
1988
Citation
Keimyung Medical Journal, Vol.7(2) : 330-334, 1988
Abstract
The hemostatic mechanism of action of collagen appears to involve both activation of the intrinsic clotting mechanism via factors XII and XI and a platelet interaction consisting of adherence and aggregation of platelets vis adenosine diphosphate release. Of many commercially available local hemostats, the microcrystalline collagen(Avitene) is known to be one of the most effective agents. Human amniotic membrane contains collagen that initiates platelet aggregation and activation of the intrinsic pathway of the clotting mechanism. The authors studied the hemostatic effectiveness of the human amniotic membrane and the results were compared with that of Avitene web, Collastat and Gelfoam. Canine liver and splenic bleeding models were used. Human amniotic membrane and Avitne web had similar effectiveness(97.2%) and were more effective than Collastat(77.8%) or Gelfoam(61.1%). First application success rates also revealed that amniotic membrane(80.6%) and Avitene web(77.8%) were more successful than others(47%). Human amniotic membrane is an effective topical hemostatic agent in experimental canine lever and splenic wounds when compared with several currently used agents and can also result in cost savings.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/14549
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
2. Keimyung Medical Journal (계명의대 학술지) > 1988
Keimyung Author(s)
손수상; 김인호; 강중신
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