계명대학교 의학도서관 Repository

Ethanol중독 흰쥐에서 총담관결찰이 혈청 및 간의 Alanine Aminotransferase 활성에 미치는 영향

Metadata Downloads
Affiliated Author(s)
김여희곽춘식
Alternative Author(s)
Kim, You HeeKwak, Chun Sik
Journal Title
Keimyung Medical Journal
Issued Date
1989
Abstract
This study was intended to observe the effect of common bile duct ligation on serum and liver alanine aminotransferase(ALT) activities in rats suffering from acute and chronic intoxication of ethanol. For chronic intoxication of ethanol, the rats were fed 5%(v/v) ethanol instead of water for 60days. Common bile duct of the same group of rats were ligated with ethanol constantly being fed. The rats were killed on the 1st, 2nd, 3rd, 7th and 14th days of the procedure to measure the cytosolic and mitochondrial ALT activities of the liver. The serum ALT activities were also measured. For acute intoxication of ethanol, 4g of ethanol were administered orally per kg of body weight as a single dose. The rats were killed at the 1.5th and 24th hours of the procedure for study. On the 14th day following common bile duct ligation, the rats were acutely intoxicated with ethanol to be killed at 1.5 the and 24th hours for measuring the activities of the above enzymes. In terms of rats liver cytosolic and mitochondrial ALT activities, no significant increase was shown in either chronically intoxicated ethanol group or acutely intoxicate ethanol group. The liver cytosolic and mitochondrial ALT activities of the common bile duct ligation groups showed a significant decrease at the 7th and the 14th days of the ligation. And the groups of acute intoxication with ethanol which was done after 14 days of the common bile duct ligation, the rats showed considerable decrease in the activities. The activities, however, both the groups that recieved the common bile duct ligation after being chronically intoxicated with ethanol which was done after 14 days of the common bile duct ligation showed far less decreases on the same time points than the group only with the common bile duct ligation. The serum ALT activities showed slight increase in acutely intoxicated ethanol group. On the other hand, both the common bile duct ligation groups and the one the received the same ligation after being chronically intoxicated with ethanol showed remarkable increase in the activities. But the activity, the groups that received the common bile duct ligation after chronical ethanol intoxication showed far more significant increases on the 7th and 14th days than the groups only with the common bile duct ligation, considerable activity increases were also shown when the groups were acutely intoxicated with ethanol after the ligation.
Alternative Title
Effect of Common Bile Duct Ligation on The Serum and Liver Alanine Aminotrazisferase Activities in Ethanol Intoxicated Rats
Department
Dept. of Biochemistry (생화학)
Publisher
Keimyung University School of Medicine
Citation
김여희 et al. (1989). Ethanol중독 흰쥐에서 총담관결찰이 혈청 및 간의 Alanine Aminotransferase 활성에 미치는 영향. Keimyung Medical Journal, 8(1), 113–121.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/14567
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 1989
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.