Keimyung Medical Journal, Vol.8(1) : 173-176, 1989
Hyperkeratosis of the nipple and areola is a skin disorder characterized clinically by thickening and discoloration of the skin of areola and/or nipple is a rare condition. About twenty cases, to the best our knowledge, have been reported in foreign literatures and only five cases in koreans to date. We report two cases of hyperkeratosis of the nipple and areola which occurred in 20-year-old woman and 16-year-old girl. The duration of disease is three years and six months, respectively. In two cases, physical examination showed thick, brownish pigmentation of both nipples and areolae and showed mild hyperkeratosis, keratotic plugging, acanthosis and marked papillomatosis histopathologically. Our two cases are belong to nevoid form by the Levy-Franckel classification. In both cases, the lesions produce no improvement to the treatment with topical medications including steroids and keratolytic agents.