Dept. of Surgery (외과학); Dept. of Pathology (병리학); Dept. of Internal Medicine (내과학)
Keimyung Medical Journal, Vol.8(1) : 194-199, 1989
Primary malignant non-Hodgkin's lymphoma of the breast is rare disease. It is estimated that the number of published cases in Western Literature is approximately 250 cases. The incidence of primary malignant lymphoma of the breast is only 0.04% to 0.52% of all malignant tumors of the breast. The rarity of the primary breast lymphoma is, suggested by Ferguson, related to the relatively small amount of lymphoid tissue in the breast as compared to the gut or lung in which primary lymphomas are much more frequent. Wiseman and Liao proposed the criteria for primary breast lymphoma: 1) Technically adequate material, 2) close apposition of lymphoma and breast tissue, 3) lack of previous extramammary lymphoma, and 4) documentation of the breast as the primary site. The age of occurence is most frequent in the sixth decade. The right breast is commonly involved and synchronous and metachronous bilateral breast lymphoma has been described on several occasions. In regard to histology, diffuse histiocytic type is most common. Radical mastectomy and radiation therapy are recommended as treatment of choice and adjuvant chemotherapy must be added in advanced cases. The prognosis is variable by the stage and histologic type. In general, nodular and/or lymphocytic type has more favorable prognosis. However the general impression is that the primary lymphoma of the breast has poor prognosis with frequent rapid progression and death. A case of primary non-Hodgkin's lymphoma(diffuse poorly differentiated lymphocytic type) of the breast in a 58-year-old woman is presented firsttime in our hospital.