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자궁경부암에 있어서 특이적 염색체변화와 flow cytometry에 의한 핵산 함량분석

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Author(s)
장성익이인환최인장김대광
Alternative Author(s)
Chang, Sung IkLee, In HwanChoi, In JangKim, Dae Kwang
Publication Year
1990
Keyword
Chromosome and DNA Content analysis
Abstract
In order to understand the specific chromosomal changes and CNA content analysis by flow cytometry in cervical cancer of Korean women, firstly we investigated cervical cancer cell line. The chromosomal number of cervical cancer cell line was hyperdipolid and prominent numerical abnormalities were in trisomy 1, 2, 6, 12, 16, 17, 18, 20, 21, 22 and tetrasomy 2. Specific Structural rearrangements were diletion(on1p22, 2p21, 3p21, 3q11, 6q23, 7p14, 7p21, 10p11, 22qll), translocation(3q11, 10p11), isochromosome (5q) and marker chromosome. Common break points at bands 1p22, 2p21, 3p21, 6q23, 22q11 give rise to the loss of cellular oncogene fgr src-2, N-myc, rafl, myb, sis respectively.
Alternative Title
Specific Cytogenetic Characteristics and DNA Content Analysis by Flow Cytometry in Cervical Cancer
Department
Dept. of Anatomy (해부학)
Dept. of Medical Genetics (의학유전학)
Publisher
Keimyung University School of Medicine
Citation
Keimyung Medical Journal, Vol.9(2) : 184-190, 1990
Type
Article
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/14623
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