자궁경부암에 있어서 특이적 염색체변화와 flow cytometry에 의한 핵산 함량분석

Abstract

In order to understand the specific chromosomal changes and CNA content analysis by flow cytometry in cervical cancer of Korean women, firstly we investigated cervical cancer cell line. The chromosomal number of cervical cancer cell line was hyperdipolid and prominent numerical abnormalities were in trisomy 1, 2, 6, 12, 16, 17, 18, 20, 21, 22 and tetrasomy 2. Specific Structural rearrangements were diletion(on1p22, 2p21, 3p21, 3q11, 6q23, 7p14, 7p21, 10p11, 22qll), translocation(3q11, 10p11), isochromosome (5q) and marker chromosome. Common break points at bands 1p22, 2p21, 3p21, 6q23, 22q11 give rise to the loss of cellular oncogene fgr src-2, N-myc, rafl, myb, sis respectively.