Doxorubicin에 의한 심근증 1례

Abstract

Doxorubicin is effective chemotherapeutic agent in the treatment of various solid tumor and hematologic malignancies. Because of its cardiotoxicity, however, early inappropriate discontinuation of doxorubicin therapy in unavoidable and may minimize its therapeutic efficacy in may patients. Doxorubicin cardoptpxicity is dose related and the cardiomyopathy is fatal in over half the cases. Authers have experienced a case of doxorubicin induced cardiomyopathy in a 4 years old girl who diagnosed dose is 345mg/M?. She also had right nephrectomy and irradiation to the right kidney area. Brief review of the literature was made.