중심성 혈액유입량의 변동에 따른 심혈관계의 변화

Other Titles
Cardiovascular Responses to Changes of Central Blood Volume in Dogs
Authors
배재훈채의업박원균
Department
Dept. of Medical Education (의학교육학); Dept. of Physiology (생리학)
Issue Date
1993
Citation
Keimyung Medical Journal, Vol.12(4) : 455-465, 1993
Abstract
The relationship between the changes of the central blood volume and the hemodynamic responses of systemic and pulmonary vessels to passive body tilts was studied. Nine dogs were passively tilted from supine to 6。, 15。and 30。head-up(HU) or to -6。, -15。and -30。head-down(HD) serially for 10 minutes in each grade. Pressures of systemic artery(SAP), pulmonary artery(PAP), pulmonary arterial wedge(PAWP), right atrium(CVP), external jugular vein(EJVP) and femoral vein(FVP) were measured. And cardiac output(CO), stroke volume(SV), heart rate(HR), end-diastolic volume(EDV), cardiac acceleration index(CAI) and thoracic fluid volume(TFV) were measured by a impedance cardiograph(BoMed Co.) Systemic vascular resistance(SVR) and pulmonary vascular resistance(PVR) were calculated by Ohm's principle. At the tilts to -6。, -15。and -30。 HD, TFV increased gradually by 29, 108 and 213ml respectively, whereas it reduced by 33, 65 and 60 ml at 6。, 15。 and 30。 HU respectively. CO increased at -6。and -15。 HD and not change at HU. HR did not change at HD, but increased at HU. SAP and SVR did not show the significant changes at both tilts. PAP decreased gradually at HD and PVR increased at HU. PAWP decreased gradually at both tilts and CVP decreased gradually at HD. EJVP increased and FVP decreased with proportion to the tilting degree at HD. But FVP decreased proportionally, whereas EJVP showed no change at HU. CAI reduced with elevated EDV at -30。 HD. In summary. a passive body tilt produces the alteration of thoracic blood volume with progress to the direction and the magnitude of a hydrostatic pressure. It seems that the cephalic vasodilation is mediated by the cardiopulmonary baroreceptors at HD tilts, and the vasoconstriction of lower extremities is mediated by the local control mechanisms as well as the cardiopulmonary receptors and arterial baroreceptors at HU tilts.
Keywords
Head-down tiltHead-up tiltPulmonary vascular hemodynamicsSystemic vascular hemodynamics
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/14844
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 1993
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Medical Education (의학교육학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
Keimyung Author(s)
박원균; 채의업; 배재훈
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