토끼의 관절연골 인공손상후 재생과정

Abstract

Articular cartilage consists of sparsely distributed chondrocytes surrounded by an elaborated highly organized macromolecular framework filled with water. Three classes of macromolecules (collagen, proteoglycan, noncollagenous protein) form the macromolecular framework. It is debatable whether chondrocyte has the ability to replicate in normal situation or damaged situation. But in general the articular cartilage is known as a tissue which does not have specific reaction in dormed state after maturation cease and in damaged portion fibrous tissue transformed to a greater or lesser extent to fibrous cartilage and the formation of an imperfect form of hyaline cartilage in occasional foci. In orthopedic department, injury to the articular cartilage can develop frequently and healing process takes major part in articular function. In this point in order to know the healing process in damaged articular cartilage, we made (cartilage)l defect including subchondrea tone on medial and lateral condyle of the rabbit femur and observed the healing process by light microscope. Through the experiment, we observed articular cartilage regeneration in subchondral defect area. Some of the subchondral defect areas of rabbit femoral cartiage become fibrillated, lose their matrix metachromasia and tend to develop chondrocyte clusters, thus mimicking human osteoarthritis and it is needed more cases and electron microscopic examination and immunochemical examination to know cartilage regeneration after cartilage injury.