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Alzheimer병

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Affiliated Author(s)
박종한
Alternative Author(s)
Park, Jong Han
Journal Title
Keimyung Medical Journal
Issued Date
1997
Keyword
Aizheimer diseaseDementia
Abstract
Alzheimer disease is a chronic neurodegenerative disease whose prevalence increase with aging. The global cognitive function including learning and memory is significantly impaired. The genetic studies revealed that beta amyloid precursor protein(APP), Apolipoprotein E₄, presenilin 1 and presenilin 2 genes are linked on the chromosome 21, 19, 14, and 1, the respectively. Whereas chromosome 21, chromosome14, and chromosome 1 are usually related with early-onset type, chromosome 19 is related with late-onset one.
Its prevalence is about 3% in 65-69 years old and 24% in above 85. Age, familial aggregation, and apolipoprotein E₄are confirmed as the risk factors.
There are many assessment tools to evaluate cognitive functions of Alzheimer disease. Structural and functioning imagings including CT, MRI, SPECT, and PET are used to diagnose Alzheimer disease.
Cholinesterase inhibitors such as tacrine is confirmed to be effective in the improvement of memory of Alzheimer patients. Other antidementic drugs are in the stage of clinical trial.
Alternative Title
Introduction to
Alzheimer Disease
Department
Dept. of Psychiatry (정신건강의학)
Publisher
Keimyung University School of Medicine
Citation
연병길 and 박종한. (1997). Alzheimer병. Keimyung Medical Journal, 16(3), 301–305.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15035
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 1997
1. School of Medicine (의과대학) > Dept. of Psychiatry (정신건강의학)
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