베체트병환자에서 회상항원에 대한 피부 지연과민반응의 연구

Abstract

To assess cell-mediated immunity of patients with Behcet's disease, many studies have been performed by in vitro method. However, there is a little known about cell-mediated immunity of patients with Bechcet's disease by in vivo method. Thus, we investigated delayed cutaneous hypersensitivity using Multitest CMI, which is a disposable applicator preloaded with 7 recall antigens, in 82 cases including 62 cases of Behect's disease and 20 cases of control, Sixty two patients with Behcet's disease were classified into 3 types : complete, incomplete and suspected type according to the revised Shimizu method. The results were obtained as follows: 1) Sum of average diameter of positive antigens was 6.71±1.10 mm in complete type of Behcet's disease, 12.59±3.48 mm in incomplete type 7.0±2.0 mm in suspected type, 11.13±3.36 in total of Behcet's disease and 20.38±6.06 mm in control. There was statistically significant difference between Behcet's disease and control (p<0.05). 2) Number of positive antigen was 1.7±0.51 in complete type, 2.29±0.89 in incomplete type, 3.0±1.0 in suspected type, 3.32±0.78 in total of Behcet's disease and 4.01±1.51 in control. There was statistically significant difference between Behcet's disease and control (p<0.05). 3) The rate of hyponergy in Behcet's disease and control was 32.2% and 0%, respectively. The rate of energy in Behcet's disease and control was 4.8% and 0%, respectively. 4) Antigens acquired strongest reaction were all tuberculin in Behcet's disease (positivity; 81%) and control (95%). Antigens acquired weakest reaction were all tetanus in Behcet's disease (7%) and control (10%). Unexpectedly, the positivity of streptococcus suggested as one of etiologic agents in Behcet's disease was 10% in Bechet's disease and 56% in control. Taken altogether, our study revealed cell-mediated immunity of Behcet's disease measured by multitest CMI was decreased and it is suggested that decreased cell-mediated immunity in Behcet's disease is related, at least in part, to the disease severity and involved in the pathogenesis of this disease.