알츠하이머 및 혈관성 치매환자에서 L-Acetyl-Carnitine의 효과

Abstract

A open clinical trial was conducted in order to evaluated the clinical efficacy and safety of L-acetyl-carnitine in patients with Alzheimer or vascular dementia. 18 patients were enrolled into this trial. The efficacy of the drugs was evaluated by itemized neurolgic check list in each months. The results were summarized as follows. 1. There were significant improvement of psychotic symptoms in 4 weeks and 12 weeks. 2. In Hasegawa dementia scale, the average scores of 12 weeks were significantly higher than the scores of base line and 4 weeks, respectively. 3. In MMSE-K, the average scores of 12 weeks were significantly higher than the scores of base line and 4 weeks, respectively. 4. The drug was safe but mild gastrointestinal disturbance was observed very rarely as adverse reaction. The administration of L-acetyl-carnitine had significantly improvement of cognitive and psychotic symptoms of patients with Alzheimer or vascular dementia. The side effects were minor and transient.