흰쥐 재생간에서 Benzoyltransferase 및 Phenylacetyltransferase의 활성도

Other Titles
Benzoyltransferase and Phenylacetyltransferase Activities in Regenerating Liver after Partial Hepatectomy in Rats
Authors
김영진김여희
Department
Dept. of Biochemistry (생화학); Institute for Medical Science (의과학 연구소)
Issue Date
1999
Citation
Keimyung Medical Journal, Vol.18(1) : 72-81, 1999
Abstract
We have investigated the effect of partial hepatectomy on the closely related acyl-CoA : amino acid N-acyltransferase, benzoyltransferase and phenylacetyltransferase activities in rat liver. Cytosolic, mitochondrial and microsomal benzoyltransferase and phenylacetyltransferase activities were determined in regenerating livers after 70% (median and left lateral lobes) partial hepatectomy in rats over a pariod of ten days. The activities of both benzoyltransferase and phenylacetyltransferase in microsome of regenerating rat liver showed a significant increase compared to the activities from the original liver from the first day to the third day after partial hepatectomy. The enzyme kinetic parameters of hepatic benzoyltransferase were analyzed using benzoyl coenzyme A as a substrate with microsomal preparations from the first day post-hepatectomy. And enzyme parameters of hepatic phenylacetyltransferase were also analyzed using phenylacetyl coenzyme A as a substrate with microsomal preparations from the first day post-hepatectomy. The results indicated that although the Km values of these enzymes were about the same as the control original liver, the Vmax values of both enzymes increased significantly. These results, therefore, suggest that the biosynthesis of hepatic microsomal benzoyltransferase and phenylacetyltransferase has been increased in the regenerating stage.
Keywords
BenzoyltransferasePhenylacetyltransferaseRegenerating rat liver
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/15124
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
1. Journal Papers (연구논문) > 3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
2. Keimyung Medical Journal (계명의대 학술지) > 1999
Keimyung Author(s)
김여희
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