신증후출혈열 회복 후 발생한 뇌하수체 기능 저하증 1례

Other Titles
A Case of Panhypopituitarysm after Recovery from He
Authors
김민수신동우김성종이상수여준기박근용서상혁곽진호
Department
Dept. of Internal Medicine (내과학); Institute for Medical Science (의과학 연구소)
Issue Date
1999
Citation
Keimyung Medical Journal, Vol.18(1) : 156-163, 1999
Abstract
Hemorrhagic fever with renal syndrome is acute viral disease caused by Hantaan virus, its clinical features are high fever, hypotension, bleeding tendency and renal failure. In the autopsy finding of hemorrhagic fever with renal syndrome, almost all patients shows coagulation necrosis of anterior pituitary gland which is known as one of the most characteristic microscopic finding but there has been rare reports of panhypopituitarysm in living patients with hemorrhagic fever with renal syndrome. Recently we have experienced one case of panhypopituitarysm patient. He was admitted our hospital under the impression of hemorrhagic fever with renal syndrome and had managed 17 years ago. After discharge he recognized general weakness, axillary and pubic hair loss but he didn't have any evalutation or treatment. 17 years later, he visited our hospital this time due to severe general weakness and febrile sensation. In patients serum, we could find high titer of antibody against Hantaan virus. The patient was confirmed as panhypopituitarysm by combined anterior pituitary function test. There was no evidence of other hypothalamic or pituitary disease by several test including sella MRI. After hormonal substitution therapy with prednisolone and thyroid hormone was started, clinical picture became normalized. We conclude that hemorrhagic fever with renal syndrome can be a cause of panhypopituitarysm and high index of suspicion should be maintained to detect hypopituitarysm in patient with past history of hemorrhagic fever with renal syndrome when appropriate symptoms and signs are present.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/15133
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. Journal Papers (연구논문) > 3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
2. Keimyung Medical Journal (계명의대 학술지) > 1999
Keimyung Author(s)
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