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만성 주정 중독 흰쥐에서 총담관 결찰이 UDP-Glucuronosyltransferase 활성에 미치는 영향

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Author(s)
조경일김여희
Publication Year
1999
Keyword
Chronic ethanol intoxicationCommon bile duct ligationUDP-Glucuron osyltransferase
Abstract
The alcoholic hazard in hepatobiliary disease was studied by the assays of liver microsomal UDP-glucuronosyltransferase activity in cholestasis induced by common bile duct (CBD) ligation after chronic ethanol intoxication in rats.
The microsomal UDP-glucuronosyltransferase activity and the Vmax value of the enzyme in the cholestatic rat liver combined with chronic ethanol intoxication showed further significant decrease compared to the activity from cholestasis alone. However, the Km value of th enzyme did not change. The results indicate that the biosynthesis of the liver UDP-glucuronosyltransferase is decreasing in chronic ethanol intoxication with cholestasis than in cholestasis alone.
Alternative Title
Effect of Common Bile Duct Ligation on Liver UDP-Glucuronsyl-transferase Activity in Chronic Ethanol Intoxicated Rats
Department
Dept. of Biochemistry (생화학)
Institute for Medical Science (의과학 연구소)
Publisher
Keimyung University School of Medicine
Citation
Keimyung Medical Journal, Vol.18(3) : 401-411, 1999
Type
Article
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/15159
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