B형 전림프구성 백혈병 1례
- 윤상미; 이홍석; 박근규; 전동석; 송홍석
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- B-prolymphocytic leukemia; Combination chemotherapy
- Prolymphocytic leukemia(PLL) first described by Galton and colleagues in 1974, is a distinct clinicopathologic variant of chronic lymphocytic leukemia. It is characterized by marked lymphocytosis, massive splenomegaly, minimal lymphadenopathy, and poor prognosis. The clinical course of PLL is generally brief, the median survival in Galton's original series was 4 months. We experienced a case of B-prolymphocytic leukemia. The patient was a 64 year-old man who presented with splenomegaly, marked leukocytosis and 65% of characteristic prolymphocytes in the peripheral blood. We report a case of PLL with a prolonged course after combination chemotherapy with daunorubicin, L-asparaginase, vincristine, prednisolone, and methotrexate.
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