유증상 동맥관 개존을 가진 만삭아에서 Mefenamic Acid(Pontal_R)의 조기 폐쇄 효과

Abstract

The Patent ductus arteriosus (PDA) is an essential structure that occurs normally in the fetus and becomes abnormal only when it persists after birth. Indomethacin, ibuprofen and mefenamic acid, prostaglandin synthetase inhibitors, have been shown to close the ductus arteriosus in a large portion of premature infant. To investigate the effect of mefenamic acid(Pontal) for the early closure of symptomatic PDA(s-PDA) in full-term infants, we analyzed twenty-nine cases who were admitted to NICU of Dong San Medical Center, Keimyung University during the period from July 1995 to June 1999. The diagnosis of s-PDA was made by clinical(Modified Yeh's criteria) and echocardiographic findings. Among 29 cases, 15 cases were treated with lasix plus mefenamic acid(Pontal group), and the other 14 cases were treated with lasix alone(control group). The rate of PDA closure and clinical courses of both groups were compared. Mean gestational age, birth weight, sex, and clinical findings have similar distribution in both groups. The closure rate within 2 weeks was significantly higher in the Pontal group(73.3%) than that of the control group(14.3%)(p<0.005), and no significant complications were identified in both groups. Mefenamic acid can be used as an effective drug for the early closure of symptomatic PDA in full-term infants with no significant side effects.