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Protein C 결핍과 허혈성 뇌졸중의 연관성

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Author(s)
김광덕강봉구허재훈박상원최종환이형이상도
Publication Year
2001
Keyword
Protein C deficiencyIschemic stroke
Abstract
The aim of this study was to
evaluate the prevalence of protein C deficiecy in ischemic stroke patients. We studied 101 consecutive patients with acute arterial ischemic stroke on computed tomography (CT) or magnetic resonance imaging (MRI). The control group consisted of 73 patients with nonvascular neurologic diseases (peripheral polyneuropathy, lumbar disc disease, Parkinson s disease, and Alzheimer’s disease). Blood samplings were performed at the acute stage of the ischemic stroke between 4 hours and 5 days after the onset of symptoms in all patients. We found abnormally depressed levels of protein C in 7 patients out of 101 patients with ischemic stroke. Four patients had a possible cause of protein C deficiency such as liver cirrhosis (n=2), anticoagulant therapy (n=l), and autoimmune disease (n-1). Among 3 patients with unknown cause of protein C deficiencym, however, 2 patients had long-standing atrial fibrillation or hypertension considered to be a cause of stroke. Therefore, only 1 patient had a protein C deficiency as a possible cause of stroke. Our results suggest that congenital deficiency of protein C does not seem to be associated with acute ischemic stroke.
Alternative Title
Protein C Deficiency
Associated with Ischemic Stroke
Department
Dept. of Neurology (신경과학)
Publisher
Keimyung University School of Medicine
Citation
Keimyung Medical Journal, Vol.20(2) : 140, 2001
Type
Article
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/15224
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