계명대학교 의학도서관 Repository

담즙울체 쥐에서 Taurocholate 부하에 의한 간의 Xanthine Oxidase 유도

Metadata Downloads
Author(s)
정상호문교철
Publication Year
2001
Keyword
Bile duct obstuctionCholedocho-caval shuntTaurocholic acidTauroursodeoxycholic acidXanthine oxidase
Abstract
Possible mechanisms of
increase of xanthine oxidase (XO) activity in cholestatic rat liver and serum were studied. These hepatic and serum enzyme activities were determined in experimental rats with choledocho-caval shunt (CCS) or bile duct obstruction (BDO). The Michaelis-Menten constant of this hepatic enzyme were also measured. The activities of hepatic and serum XO as well as the Vmax value of this hepatic enzyme were found to be significantly increased in both CCS plus taurocholic acid (TCA) injected group, and BDO plus TCA injected group than in the control groups such as CCS alone and BDO alone. In addition, these serum and hepatic XO activities did not change in both the CCS plus tauroursodeoxycholic acid (TUDCA) injected group and the BDO plus TUDCA injected group. On the other hand, the Km value of the above hepatic enzyme did not change in any experimental group. Above results suggest that TCA induces biosynthesis of XO in the liver. The elevated activity of serum XO is most likely caused by increased hepatocytes membrane permeability due to TCA mediated liver cell necrosis.
Alternative Title
Induction of
Hepatic Xanthine Oxidase by Taurocholate in Cholestatic Rats
Department
Dept. of Biochemistry (생화학)
Publisher
Keimyung University School of Medicine
Citation
Keimyung Medical Journal, Vol.20(2) : 172, 2001
Type
Article
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/15228
Authorize & License
  • AuthorizeOpen
Files in This Item:

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.