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Activities of Antioxidant Enzymes in Neutrophils from Patients with Diabetes Mellitus

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Author(s)
문교철
Alternative Author(s)
Mun, Kyo Cheol
Issued Date
2002
Keyword
NeutrophilsCatalaseGlutathione peroxidaseSuperoxide dismutase
Abstract
To know the mechanism of impaired bactericidal function, especially
impaired hydrogen peroxide production, in neutrophils from patients with diabetes
mellitus, the activities of antioxidant enzymes such as superoxide dismutase,
catalase, and glutathione peroxidase were determined in neutrophils from 12
patients with diabetes mellitus. Catalase activity in the neutrophils from the
patients with diabetes mellitus were higher than that from healthy controls
(P<0.05). Glutathione peroxidase activity in the neutrophils was higher without
significance. Superoxide dismutase activity in the neutrophils was lower without
significance. These results suggest that the production of hydrogen peroxide exerting
a direct germicidal ability is impaired in patients with diabetes mellitus due to
the decrease in dismutation of superoxide radicals by superoxide dismutase and
the increase in dismutation of hydrogen peroxide by catalase and glutathione peroxidase,
and these alterations might affect microbicidal activity of neutrophils in
patients with diabetes mellitus.
Department
Dept. of Biochemistry (생화학)
Publisher
Keimyung University School of Medicine
Citation
Keimyung Medical Journal, Vol.21(1) : 1-6, 2002
Type
Article
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/15234
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2002
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
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