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Effect of High Concentration of Uremic Toxin on Erythropoiesis in Acute Blood Loss

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Author(s)
문교철
Alternative Author(s)
Mun, Kyo Cheol
Issued Date
2002
Keyword
Acute blood lossAnemiaCyanateEnd-stage renal diseasesErythropoietin
Abstract
During advanced renal failure, and particularly in patients with
end-stage renal diseases (ESRD), proteins are carbamylated and lose biological
activity as the result of a reaction with cyanate which is derived from urea. The
effect of cyanate on the erythropoietic activity of erythropoietin (EPO) after acute
blood loss in rats was studied. EPO was incubated with cyanate at 37℃. The erythrocytes
count, hemoglobin concentration, hematocrit and leukocytes were measured
after the subcutaneous injection of either normal saline, cyanate, EPO, or
incubated EPO with cyanate. Normal saline or 1 M cyanate injected controls and
the incubated EPO with cyanate injected animals demonstrated decrease from day
zero in erythropoietic parameters. The parameters maintained in EPO injected
group. These results support that EPO exposed to cyanate in vitro demonstrates
diminished biologic activity in acute blood loss. This effect suggest that EPO is
inhibited in the presence of cyanate under the stimulatory condition for EPO, and
it may contribute to the suboptimal erythropoietic response to EPO therapy associated
with high urea levels, especially related to inadequate dialysis.
Department
Dept. of Biochemistry (생화학)
Publisher
Keimyung University School of Medicine
Citation
Keimyung Medical Journal, Vol.21(1) : 21, 2002
Type
Article
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/15236
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2002
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
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