계명대학교 의학도서관 Repository

담즙울체 쥐에서 간 라이소솜의 α-D-Glucosidase와 β-D-Glucuronidase 활성도에 미치는 Taurocholate의 정맥 내 투여의 영향

Metadata Downloads
Author(s)
김여희곽춘식
Alternative Author(s)
Kim, You HeeKwak, Chun Sik
Publication Year
2002
Keyword
α-D-Glucosidaseβ-D-Glucuronidase
Abstract
The effects of intravenously administered of high concentration of
taurocholic acid (TCA) on α-D-glucosidase and β-D-glucuronidase activities in rat
liver lysosomes were studied. These liver lysosomal enzymes, and serum lysosomal
α-D-glucosidase and total β-D-glucuronidase activities were also determined in
experimental rats with common bile duct ligation (CBDL). The activities of liver
lysosomal α-D-glucosidase and β-D-glucuronidase as well as the activities of serum
α-D-glucosidase and total β-D-glucuronidase were found to be significantly
increased in the CBDL plus TCA injected group than in the control group such as
CBDL alone group. On the other hand, these serum and hepatic enzymes activities
did not change in the CBDL plus tauroursodeoxycholic acid injected group.
The above results suggest that TCA induces biosynthesis of the lysosomal α-D-glucosidase
and β-D-glucuronidase in the liver and that the elevated lysosomal α-D
-glucosidase and total β-D-glucuronidase activities in the serum are most likely
due to increased hepatocyte membrane permeability caused by TCA mediated liver
cell necrosis.
Alternative Title
Effect of Intravenous
Administration of Taurocholate on Liver
Lysosomal α-D-Glucosidase and β-D-Glucuronidase
Activities in Rats with Extrahepatic Cholestasis
Department
Dept. of Biochemistry (생화학)
Publisher
Keimyung University School of Medicine
Citation
Keimyung Medical Journal, Vol.21(1) : 91, 2002
Type
Article
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/15244
Authorize & License
  • AuthorizeOpen
Files in This Item:

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.