계명대학교 의학도서관 Repository

총담관을 결찰한 쥐에서 간의 Phenylacetyltransferase 활성도에 미치는 Taurocholate의 정맥 내 투여의 영향

Metadata Downloads
Author(s)
김여희곽춘식
Alternative Author(s)
Kim, You HeeKwak, Chun Sik
Issued Date
2002
Keyword
Common bile duct ligationPhenylacetyltransferaseTaurocholic acid
Abstract
The effect of intravenous administeration of high dose taurocholate
on phenylacetyltransferase (PAT) activity was studied in rat liver. PAT activity,
and it’s Km and Vmax values were determined in the liver cytosolic,
mitochondrial and microsomal fractions isolated from the common bile duct (CBD)
ligated rats, which were injected with taurocholic acid (TCA), The activities of
liver cytosolic, mitochondrial and microsomal PAT as well as their Vmax values
were found to be significantly increased in the CBD ligation plus TCA injected
group than in the control group, such as CBD ligation alone group. However, their
Km values in the experimental group did not vary. On the other hand, these hepatic
enzyme activities did not change in the CBD ligation plus tauroursodeoxycholic
acid injected group. Therefore, the above results indicate that TCA stimulates
biosynthesis of the PAT in the liver
Alternative Title
Effect of Intravenous
Administration of Taurocholate on Hepatic
Phenylacetyltransferase Activity in Common Bile Duct Ligated Rats
Department
Dept. of Biochemistry (생화학)
Publisher
Keimyung University School of Medicine
Citation
Keimyung Medical Journal, Vol.21(2) : 202, 2002
Type
Article
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/15256
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2002
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
Authorize & License
  • AuthorizeOpen
Files in This Item:

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.