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위아전절제술 및 Billroth-II 문합술 후 잔위에서의 H. Pylorl 감염 및 조직소견

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Author(s)
박경식
Alternative Author(s)
Park, Kyung Sik
Issued Date
2002
Keyword
Bile acidHelicobacter pyloriReflux gastritis
Abstract
Unconjugated bile acids inhibit the survival of Helicobacter pylori by
modifying it's ultrastructure. The prevalence of H.pylori infection after subtotal
gastrectomy and Billroth-II anastomosis has been known to be lower than that of
intact stomach due to frequent contact with bile acids. In the present study,
differences between anastomosis site and fundus were studied in 48 patients who
had been undergone subtotal gastrectomy with Billroth-II anastomosis, because of
gastric cancer. Total 26 men and 22 women were involved, and average duration
between operation and endoscopic examination was 46.3 months (median 32.5
months). Three pieces of tissue were taken at both anastomosis site and fundus,
and one piece was used for rapid urease test and others for histological
examination. The Sydney system was used to classify the extent of gastritis. The
prevalence of H.pylori infection was lower and the grade of intestinal metaplasia
was higher in anastomosis site, however there were no differences in the grades of
inflammation, activity, and atrophy between the two sites. The prevalence of
H.pylori infection in anastomosis site was higher in the group of shorter
postoperative duration. The grades of inflammation and activity at both sites were
higher in the H.pylori-positive group. In conclusion, it is suggested that bile acids
inhibit the survival of H.pylori and aggravate intestinal metaplasia, and that
H.pylori has positive correlation with the grade of gastritis in remnant stomach
Alternative Title
H. pylori Infection
and Histologic Findings in Remnant Stomach
after Subtotal Gastrectomy and Billroth-II Anastomosis
Department
Dept. of Internal Medicine (내과학)
Publisher
Keimyung University School of Medicine
Citation
Keimyung Medical Journal, Vol.21(2) : 211, 2002
Type
Article
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/15257
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2002
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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