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만성 주정중독 쥐에서 간의 Rhodanese 활성도에 미치는 간외성 담즙울체의 영향

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Author(s)
문교철김여희곽춘식
Alternative Author(s)
Mun, Kyo CheolKim, You HeeKwak, Chun Sik
Issued Date
2002
Keyword
Alcohol intoxicationCholestasisRhodanese
Abstract
To investigate the adverse effects of alcohol ingestion on the liver of
hepatobiliary disease, the activity of rat serum and hepatic rhodanese was
measured in extrahepatic cholestasis induced by common bile duct (CBD) ligation
after chronic ethanol intoxication. Liver cytosolic, mitochondrial and microsomal
rhodanese activities in CBD ligated rats with chronic ethanol intoxication were
found to be decreased much more than that in CBD ligation alone. Vmax values of
the liver cytosolic and mitochondrial rhodanese in these animals were lower than
in the control, whereas Km values of the above hepatic enzymes did not vary in
the all experimental groups. On the other hand, serum rhodanese activity in CBD
ligated rats with chronic ethanol intoxication was greater increased more than
that in CBD ligation alone. These results indicate that the biosynthesis of the
hepatic rhodanese decreases and the serum rhodanese activity increases in
cholestasis combined with chronic ethanol intoxication, reflecting damages of
aggravated hepatocytic membrane.
Alternative Title
Effect of
Extrahepatic Cholestasis on Hepatic Rhodanese
Activity in Chronic Ethanol Intoxicated Rats
Department
Dept. of Biochemistry (생화학)
Publisher
Keimyung University School of Medicine
Citation
Keimyung Medical Journal, Vol.21(2) : 218, 2002
Type
Article
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/15258
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2002
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
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