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흰쥐 재생간에서의 Thiol Methyltransferase 활성도

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Author(s)
문교철곽춘식
Alternative Author(s)
Mun, Kyo CheolKwak, Chun Sik
Issued Date
2002
Keyword
Partial hepatectomyRegenerating rat liverThiol methyltransferase
Abstract
Changes of thiol methyltransferase (TMT) activity, and it's Km and
Vmax values in cytosolic, mitochondrial and microsomal fractions in regenerating
rat livers were determined over a period of ten days after 70% partial (median
and left lateral lobes) hepatectomy. The enzyme activity in serum was also
measured. Mitochondrial and microsomal TMT activities after partial hepatectomy
were found to be significantly increased between the first and the second day, and
between the twelfth hour and the third day of regeneration, respectively, whereas
the cytosolic TMT activity increased at the second day after partial hepatectomy.
On the other hand, the serum TMT activity did not change. The Vmax values of
the cytosolic, mitochondrial and microsomal TMTs were significantly increased at
the second day after partial hepatectomy. However, the Km values of the above
hepatic enzymes did not vary in all the experimental groups. Therefore, the above
results indicate that the biosynthesis of TMT was increased during regeneration of
rat liver.
Alternative Title
Thiol
Methyltransferase Activity in Regenerating
Liver after Partial Hepatectomy in Rats
Department
Dept. of Biochemistry (생화학)
Publisher
Keimyung University School of Medicine
Citation
Keimyung Medical Journal, Vol.21(2) : 244, 2002
Type
Article
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/15260
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2002
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
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