계명대학교 의학도서관 Repository

폐포자층 폐렴의 실험적 모델

Metadata Downloads
Author(s)
정혜라권건영
Alternative Author(s)
Jung, Hye RaKwon, Kun Young
Publication Year
2003
Keyword
Animal modelMorphologic characteristicsPneumocystis carinii
Abstract
Pneumocystis carinii (P. carinii) is an opportunistic pathogen which
causes pneumonia in the lungs of immunocompromised patients. Since the
organism has not been successfully propagated in vitro, many investigators have
been restricted to in vivo models for studing the P. carinii organisms. This study
was carried out to investigate more desirable animal model of P . carinii
pneumonia and to observe morphologic characteristics in the animal model of rats.
After six weeks of administration of 8% low protein diet, dexamethasone,
tetracycline, and nystatin, the Sprague-Dawley rats were sacrificed to submit
lungs and bronchoalveolar lavage for the study. We compared between the oral
administration and intraperitoneal injection of dexamethasone to the experimental
rats. The oral administration of dexamethasone was more effective than the
intraperitoneal injection of dexamethasone for the survival rates and detection
rates of P. carinii in the rats. The survival rates and detection rates of P. carinii
were similar between the group of intratracheal injection of P. carinii plus oral
dexamethasone administration and the group of only oral dexamethasone
administration. These results indicated that the oral administration of
dexamethasone in the experimental rats is more convenient and effective method
to make a desirable P. carinii animal model and to observe morphologic
characteristics of P. carinii pneumonia in rats.
Alternative Title
Experimental Model
of Pneumonia Induced by
Pneumocystis carinii
Department
Dept. of Pathology (병리학)
Publisher
Keimyung University School of Medicine
Citation
Keimyung Medical Journal, Vol.22(1) : 68-80, 2003
Type
Article
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/15267
Authorize & License
  • AuthorizeOpen
Files in This Item:

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.