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Co-expression of Cholecystokinin and Neuropeptide Y by Glutamatergic Stimulation in PC12 Cells

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Affiliated Author(s)
김수경
Alternative Author(s)
Kim, Soo Kyung
Journal Title
Keimyung Medical Journal
Issued Date
2003
Keyword
CholecystokininGlutamatergic stimulationNeuropeptide YPC12 cell
Abstract
Co-expression of cholecystokinin (CCK) and neuropeptide Y (NPY) by glutamatergic stimulation was examined by double stained immnocytochemistry in the rat PC12 cells. Co-expression of CCK and NPY was inducible by glutamate and N-methyl-D-aspartate (NMDA), but not by kainic acid. Pretreatment of the cells with non-competitive NMDA antagonist, MK-801 (10 µM), and competitive NMDA antagonist, AP5 (10 µM), slightly suppressed the elevated levels of glutamate-induced CCK and NPY immunoreactivity, but markedly inhibited those of NMDA-induced CCK and NPY immunoreactivity. These results suggest that CCK and NPY expressions are mainly regulated through the NMDA-induced signaling pathways, and both molecules could be co-expressed via NMDA receptors upon glutamatergic neuroexcitation at the synaptic junction.
Department
Dept. of Pharmacology (약리학)
Publisher
Keimyung University School of Medicine
Citation
권지윤 and 김수경. (2003). Co-expression of Cholecystokinin and Neuropeptide Y by Glutamatergic Stimulation in PC12 Cells. Keimyung Medical Journal, 22(별호), 11–17.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15296
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2003
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
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