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Streptozotocin에 의해 유도된 당뇨 쥐의 췌장에 대한 Melatonin의 효과

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Author(s)
문교철한승엽김상표
Alternative Author(s)
Mun, Kyo CheolHan, Seung YeupKim, Sang Pyo
Issued Date
2006
Keyword
AntioxidantDiabetes mellitusMelatoninStreptozotocin
Abstract
The effect of melatonin, a powerful antioxidant, on the pancreas of the diabetes mellitus induced by streptozotocin in male rats was studied. Diabetes was induced by the intraperitoneal injection of 65 mg of streptozotocin per kg of body weight. To know the effect of melatonin, total 10 mg of melatonin per kg of body weight was administered intraperitoneally at the time of streptozotocin and 72 hours after the first administration. Then the rats were sacrificed at the 7 th day after the first injection. Several biochemical parameters, microscopic examination and immunohistochemical stain were done. The injection of streptozotocin caused significant increases in the blood levels of glucose and hemoglobin A1C, and pancreatic levels of
hydrogen peroxide and malondialdehyde. Streptozotocin treated group showed the decrease of
islets and insulin-immunoreactive cells, and degenerated B cell granules. The injection of
melatonin reduced the blood levels of glucose and hemoglobin A1C, and reduced pancreatic levels of hydrogen peroxide and malondialdehyde. Melatonin caused significant increases in the levels of total antioxidant status, superoxide dismutase and catalase. The melatonin treated group showed
relatively well preserved cell organelles and Langerhan's islets under the microscopic
examination. And the melatonin treated group showed the significant increase in number of insulin-immunoreactive cells compared with streptozotocin treated group under the immunohistochemical stain. These results may suggest that melatonin has a protective effect on the pancreatic islets in the diabetes induced by streptozotocin from oxidative damage by the increase of total antioxidant status via the increased activity of antioxidant enzymes.
Alternative Title
Effect of Melatonin on the Pancreas of the Diabetes Mellitus Induced by Streptozotocin in Rats
Department
Dept. of Biochemistry (생화학)
Dept. of Internal Medicine (내과학)
Dept. of Pathology (병리학)
Publisher
Keimyung University School of Medicine
Citation
Keimyung Medical Journal, Vol.25(2) : 132-145, 2006
Type
Article
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/15376
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2006
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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