Pediatric Oncology Group(POG) 9005/9006 프로토콜을 이용한 급성 림프모구 백혈병의 치료 경험

Abstract

Recently, about 80% of the long term survival rate of children with acute lymphoblastic leukemia (ALL) can be expected due to a drastically advanced medical treatment. In Korea many cases are treated with either the various international or self-modified protocols. Dongsan Medical Center has been using POG 9005 (standard risk) / 9006 (high risk) protocol developed by Pediatric Oncology Group (POG). This study was conducted to analyze the result of the protocol developed by POG as no result of treatment utilizing the protocol was yet reported in Korea. This study was analyzed among the results of 11 children with ALL who were treated with the POG protocol at Dongsan Medical Center during the period from December 1993 to January 2005. The ages of 11 children ranged from l to 12 years and 9 boys and 2 girls with 7 in standard risk group and 4 in high risk group. The median WBC count was 27,160/μL (1,670-229,000). Three patients died. Five years of survival rate was 72.7%, event free survival rate was 72.7% and overall survival rates for the high risk and medium risk groups were 75% and 71%(p=0.997) respectively. For EFS, it showed 75% in protocol 9006 and 71% in protocol 9005 which indicated the result of high risk group favourable but it was not statistically significant. As the analysis was performed on a small number of patients, the result of high risk group might be better than that of standard risk group, however, statistically it was not significant. Further comparison with the multicenter clinical trial will be needed.