소아 마이코플라즈마 폐렴에서 clarithromycin 정주요법의 효능

Abstract

Intravenous clarithromycin therapy (ICT) for mycoplasma pneumonia in children and adolescent is one of the effective treatment modality, but most of the comparison studies with other modalities were done in adults. This study aimed to assess the characteristics and effectiveness of ICT for mycoplasma pneumonia in children and adolescent. From March 2006 to December 2007, 34 patients were treated with ICT and 71 patients with non-ICT, which were considered to be control group. Preadmission characteristics and responsiveness were analyzed retrospectively. The mean age of ICT and control group were 5.7 and 4.2 years old respectively. And there was significant difference (p=0.005). The mean preadmission fever duration were 4.9 day in ICT group and 3.3 day in control group (p=0.04). No other preadmission parameters showed statistically significant differences. Average fever duration after initiation of antibiotics in ICT group was less than in control group(0.12 day vs. 0.61 day ; p=0.03), However there was no statistically significant differences in duration of admission and readmission rate between two groups. These results show that intravenous clarithromycin therapy may be a good choice for the treatment of mycoplasma pneumonia in children and adolescent especially if the fever duration was prolonged.