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Cisplatin에 의해 유도된 신장 손상시의 유전자 발현

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Affiliated Author(s)
곽춘식하은영김여희문교철황은아박성배김현철
Alternative Author(s)
Kwak, Chun SikHa, Eun YoungKim, You HeeMun, Kyo CheolHwang, Eun AhPark, Sung BaeKim, Hyun Chul
Journal Title
Keimyung Medical Journal
Issued Date
2009
Keyword
CisplatinGene expressionRenal Damage
Abstract
Cisplatin, an antitumor agent widely used in the treatment of a variety of human solid tumors, has nephrotoxicity. To understand the mechanism for the nephrotoxicity, the gene expression patterns of renal tissues were measured. Sprague-Dawley rats received a single intraperitoneal injection of 8 mg/kg of cisplatin and sacrificed 6 days after cisplatin injection. The genes showed significant changes in expression are 111 genes, are associated with a broad range of functional activities, including apoptosis, cell cycle, cell growth/maintenance, immunoresponse, response to stress, signal transduction, transcription, and metabolism. The expression of the fifty two genes was increased, and that of fifty nine genes was decreased. Especially, the expression of the genes associated with apoptosis such as Spp1, Tubb5, Hmox1 and Clu was increased. And the expression of the genes associated with cell cycle such as Pttg1, Ccng1 and Anxa1 was also increasd. These results suggest that cisplatin induce nephrotoxicity by the changes of gene expression involved in apoptosis and cell cycle.
Alternative Title
Gene Expression in the Renal Damage Induced by Cisplatin
Department
Dept. of Biochemistry (생화학)
Dept. of Internal Medicine (내과학)
Kidney Institute (신장연구소)
Publisher
Keimyung University School of Medicine
Citation
백철민 et al. (2009). Cisplatin에 의해 유도된 신장 손상시의 유전자 발현. Keimyung Medical Journal, 28(1), 17–26.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15423
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2009
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
3. Research Institutues (연구소) > Kidney Institute (신장연구소)
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