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신장에서 cisplatin이 활성산소 대사에 미치는 영향

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Affiliated Author(s)
곽춘식하은영김여희문교철황은아박성배김현철
Alternative Author(s)
Kwak, Chun SikHa, Eun YoungKim, You HeeMun, Kyo CheolHwang, Eun AhPark, Sung BaeKim, Hyun Chul
Journal Title
Keimyung Medical Journal
Issued Date
2009
Keyword
CisplatinKidneyReactive oxygen species
Abstract
Cisplatin, an antitumor agent widely used in the treatment of a variety of human solid tumors, has nephrotoxicity. To understand the mechanism for the nephrotoxicity, oxidative stress markers levels and activities of antioxidative enzymes were measured. Sprague-Dawley rats received a single intraperitoneal injection of 8 mg/kg of cisplatin and sacrificed 6 days after cisplatin injection. When mitochondria was exposed to cisplatin, the oxygen free radical production was increased depending on the exposure time. Cisplatin treated rats showed the increase of hydrogen peroxide levels and xanthine oxidase activity in serum. However, catalase activity was decreased. The mRNA expression for renal superoxide dismutase was decreased in
the cisplatin treated rats. These results suggest that cisplatin induces nephrotoxicity is
associated with the production of reactive oxygen species via the changes of the antioxidant enzymes.
Alternative Title
Effect of Cisplatin on the Metabolism of the Reactive Oxygen Species in Kidney
Department
Dept. of Biochemistry (생화학)
Dept. of Internal Medicine (내과학)
Kidney Institute (신장연구소)
Publisher
Keimyung University School of Medicine
Citation
백철민 et al. (2009). 신장에서 cisplatin이 활성산소 대사에 미치는 영향. Keimyung Medical Journal, 28(1), 53–62.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15427
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2009
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
3. Research Institutues (연구소) > Kidney Institute (신장연구소)
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