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유방암종의 HER2 종양단백의 면역조직화학적 발현

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Affiliated Author(s)
정혜라권선영강유나권건영김상표이상숙
Alternative Author(s)
Jung, Hye RaKwon, Sun YoungKang, Yu NaKwon, Kun YoungKim, Sang PyoLee, Sang Sook
Journal Title
Keimyung Medical Journal
Issued Date
2009
Keyword
Breast carcinomaHER2Immunohistochemistry
Abstract
Immunohistochemistry (IHC) is very simple method to evaluate the HER2 status in breast carcinoma. The aim of this study was to determine the potential value of the immunohistochemistry(IHC) using CB11 monoclonal antibody as a first-line screening of HER2
overexpression. The HER2 status of 198 consecutive cases of breast carcinoma was studied. Tissue arrays made from the representative portion of each breast carcinoma specimen were used for conventinal IHC using CB11 monoclonal antibody and HercepTest. Expression of HER2 of both methods was assessed by HercepTest scoring system of 0, 1+, 2+, and 3+. The result of IHC using CB11 monoclonal antibody correlated significantly with the HercepTest (concordance: 84.3%, kappa=0.704). It is highly suggested that IHC of CB11 monoclonal antibody can be used as a first-line test to explore the overexpression of HER2 by HercepTest.
Alternative Title
Immunohistochemical Expression of HER2 Oncoprotein in Breast Carcinoma
Department
Dept. of Pathology (병리학)
Publisher
Keimyung University School of Medicine
Citation
정혜라 et al. (2009). 유방암종의 HER2 종양단백의 면역조직화학적 발현. Keimyung Medical Journal, 28(2), 182–190.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15443
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2009
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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