조골세포에서 시안산에 의한 유전자 발현
- Affiliated Author(s)
- 하은영; 문교철; 황은아; 박성배
- Alternative Author(s)
- Ha, Eun Young; Mun, Kyo Cheol; Hwang, Eun Ah; Park, Sung Bae
- Journal Title
- Keimyung Medical Journal
- Issued Date
- 2009
- Keyword
- Cyanate; End-stage renal disease; Microarray; Osteoblast
- Abstract
- Renal osteodystrophy(ROD) contributes as a major long-term complication which is associated with high rate of morbidity. The factors contributing to ROD are still incompletely characterized. Cyanate, known as one of the uremic toxins, is derived spontaneously from urea. According to previous studies, cyanate appears to play a role as a trigger for apoptosis by activating proapoptotic signals in osteoblasts. The purpose of this study is to detect the gene expression by cyanate in osteoblasts. Microarray for 4,800 genes to detect gene expression was performed using ROS 17/2.8 cells incubated with 20 mmol/L cyanate. About twenty percent of the
genes among 4,800 genes were expressed by cyanate, and most of the expressed genes except the genes which are related stress were inhibited by cyanate. According to these results, cyanate may play a role in the pathogenesis of ROD due to plays as one of the stress factors and the inhibitor for gene expression in osteoblasts.
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