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자궁경부암 선별검사로서 인유두종바이러스 DNA 검사의 임상적 유용성

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Affiliated Author(s)
류남희하정숙전동석김재룡조치흠
Alternative Author(s)
Ryoo, Nam HeeHa, Jung SookJeon, Dong SeokKim, Jae RyongCho, Chi Heum
Journal Title
Keimyung Medical Journal
Issued Date
2009
Keyword
Cervical cancerHPVHybrid capturePap smear
Abstract
In spite of the enforcement of the screening program by cervical cytology (Pap smear), false negativity of conventional cytology is problematic and the sensitivity of cytology is highly variable. Therefore, newly developed tests based on molecular method to detect Human Paillomavirus (HPV) DNA have been introduced. Authors evaluated the sensitivity and specificity with efficacy of HPV DNA test as a screening test for cervical cancer according to the biopsy which is a gold standard method. Thirty-three of 52 (63.4%) patients who showed higher grade of severity than CIN II in biopsy were all positive (100%) in HPV DNA test, but Pap smear showed negative in one patient. Among 62 patients with positive HPV DNA but without results of cervical biopsy, 7 patients later revealed advancement of cytological findings during the first year of follow-up. Since HPV DNA test showed higher sensitivity and negative predictive value for the detection of high-grade cervical lesions than cytology, it would be clinically efficiently used as a primary screening test for cervical cancer. In addition, more effective guidelines for combined usage with cytology would need to be established and further studies would also be required.
Alternative Title
Clinical efficiency of HPV DNA test as a screening test of cervical cancer
Department
Dept. of Laboratory Medicine (진단검사의학)
Dept. of Obstetrics & Gynecology (산부인과학)
Publisher
Keimyung University School of Medicine
Citation
김지혜 et al. (2009). 자궁경부암 선별검사로서 인유두종바이러스 DNA 검사의 임상적 유용성. Keimyung Medical Journal, 28(2), 279–285.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15455
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2009
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
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