불임증 427례에 대한 세포유전학적 분석: 단일 기관 연구

Other Titles
Cytogenetic Study for 427 Patients with Reproductive Failure: Single Center Study
Authors
김도훈하정숙
Department
Dept. of Laboratory Medicine (진단검사의학)
Issue Date
2010
Citation
Keimyung Medical Journal, Vol.29(1) : 29-34, 2010
Abstract
Our study was performed to investigate the prevalence and diversity of chromosomal abnormalities in 427 patients with reproductive failure in our institution. Chromosomal aberrations were found in 5.2% of patients (6.8% in men and 3.1% in women). The most common aberration was sex chromosomal aneupolidy/mosaicism including 47,XXY in men and the reciprocal translocations in women. In 266 patients with repeated pregnany loss, the chromosomal aberration was found in 2.7% of patients (3.0% in men and 2.2% in women). The reciprocal translocation was the most common aberration in repeated preganancy loss. The normal variant chromosomal changes were found in 3.3% of all patients. The prevalence of chromosomal abnormalities found in our institution was similar with those of previous studies. However, the incidence of sex chromosomal mosaicism in female patients was relatively low, which might be due to small patient number, the difference of inclusion criteria or failure in detection of low-grade mosaicism.
Keywords
Chromosomal abnormalityCytogenetic studyInfertilityRepeated pregnancy loss
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/15489
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2010
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
Keimyung Author(s)
김도훈; 하정숙
File in this Item
29-29.pdf(159.98 kB)Download
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE