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불임증 427례에 대한 세포유전학적 분석: 단일 기관 연구

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Affiliated Author(s)
김도훈하정숙
Alternative Author(s)
Kim, Do HoonHa, Jung Sook
Journal Title
Keimyung Medical Journal
Issued Date
2010
Keyword
Chromosomal abnormalityCytogenetic studyInfertilityRepeated pregnancy loss
Abstract
Our study was performed to investigate the prevalence and diversity of chromosomal
abnormalities in 427 patients with reproductive failure in our institution. Chromosomal aberrations
were found in 5.2% of patients (6.8% in men and 3.1% in women). The most common aberration was sex chromosomal aneupolidy/mosaicism including 47,XXY in men and the reciprocal translocations in women. In 266 patients with repeated pregnany loss, the chromosomal aberration was found in 2.7% of patients (3.0% in men and 2.2% in women). The reciprocal translocation was the most common aberration in repeated preganancy loss. The normal variant chromosomal changes were found in 3.3% of all patients. The prevalence of chromosomal abnormalities found in our institution was similar with those of previous studies. However, the incidence of sex chromosomal mosaicism in female patients was relatively low, which might be due to small patient number, the difference of inclusion criteria or failure in detection of low-grade mosaicism.
Alternative Title
Cytogenetic Study for 427 Patients with Reproductive Failure: Single Center Study
Department
Dept. of Laboratory Medicine (진단검사의학)
Publisher
Keimyung University School of Medicine
Citation
김도훈 and 하정숙. (2010). 불임증 427례에 대한 세포유전학적 분석: 단일 기관 연구. Keimyung Medical Journal, 29(1), 29–34.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15489
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2010
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
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