Bone Marrow and Multiple Extra-Pulmonary Relapses of Pulmonary Marginal Zone B-cell Lymphoma - A Case Report

Abstract

Pulmonary marginal zone B-cell lymphoma of the MALT type (P-MZL) is a subgroup of extranodal MZL that arises in a number of epithelial tissues. In Korea, MZL accounts for 17% of all B-cell lymphoma. P-MZL is less than 1% of all non-Hodgkin’s lymphoma, and only 0.5~1% of primary pulmonary malignancies. The growth pattern of MZL is typically characterized by an indolent clinical course and long survival. Over its long survival duration, MZL presents frequent relapses, but bone marrow involvement of relapsed MZL is very rare. Here, we report a case of bone marrow, submandibular gland and axillary lymph nodes relapses of P-MZL after treatment with radiotherapy.