간세포암에서 간동맥 항암-방사선요법과 간동맥 항암 단독요법의 비교

Abstract

Background/Aims : Patients with advanced hepatocellular carcinoma showed a poor prognosis and there is no curative therapy. The aim of this study was to compare the therapeutic efficacy of concurrent chemoradiotherapy (CCRT) and hepatic arterial infusion therapy (HAIT) in advanced HCC. Methods : Between April 2004 and April 2009, thirty four patients (CCRT; 15 and HAIT; 19) with advanced HCC (BCLC stage C) were included in this study. The patients received 5-FU (250 mg)/ Cisplatin 10 mg)/leucovorin (12 mg) for 5 days every 3 weeks via implanted chemoport. In CCRT group, patients were treated with external beam radiotherapy (4500 cGy/5 weeks) in addition to HAIT. After 2 cycles of all these therapies, abdominal CT and serum α-FP were checked to evaluate therapeutic efficacies. Results : In patients treated with CCRT or HAIT, response rates after 2 cycles were 73.3% (PR 11, SD 2, PD 2) vs 10.5% (PR 2, SD 9, PD 8), respectively (p=0.001). The median survival time of CCRT group was 142 days compared with 166 days for HAIT (p=0.577). Conclusions : CCRT can achieves more favorable results in advanced HCC with good reserve liver function compared with HAIT but there was no differences in median survival times between two groups, Thus further investigation is required to assess long term response rate and overall survival.