임상가검물에서 분리된 대장균의 항균제 감수성

Abstract

One hundred and forty-six Escherichia coli isolated from various clinical specimens in Daegu area were tested for antimicrobial drug susceptibility to 32 drugs including cefepime, meropenem, levofloxacin and moxifloxacin. Escherichia coli were most frequently isolated from urine (59.6%), and followed by blood (18.5%), sputum (11.6%) and etc. All strains were susceptible to imipenem, meropenem and doxycycline. Only 1.4-9.6% of the strains were resistant to cefoperazone, cefotaxime, cefepime, aztreonam, amikacin, and rifampin. The resistance frequencies of amoxicillin/clavulanate, cephalothin, cefaclor, cefamandole, cefoxitin, streptomycin, kanamycin, gentamicin, netilmicin, tobramycin, norfloxacin, ofloxacin, levofloxacin, moxifloxacin, chloramphenicol and tetracycline were 15.1-33.6%. The resistance frequencies of ampicillin, nalidixic acid, ciprofloxacin, sulfisoxazole, trimethoprim and cotrimoxazole were 39.7-61.6%. All strains were resistant to erythromycin. MIC90 of cefoperazone, cefotaxime, aztreonam, imipenem, amikacin, doxycycline and rifampin were 4-16 μg/mL, and those of ampicillin, amoxicillin/clavulanate, cefamandole, cefoxitin, netilmicin, tobramycin, norfloxacin, and ciprofloxacin were 32-128 μg/mL. MIC90 of cephalothin, cefaclor, streptomycin, kanamycin, gentamicin, nalidixic acid, tetracycline, sulfisoxazole, trimethoprim and cotrimoxazole were 256 to more than 2048 μg/mL. Isolation frequencies of multidrug resistant strains were very high. Forty four (35.7%) strains were multiply resistant to 11-26 drugs and 22 (17.9%) strains were multiply resistant to 6-10 drugs.