전신홍반루푸스 환자에서 발견된 Anti-HAV IgM양성 1례

Abstract

Many studies have been reported on the complex association between viruses and systemic lupus erythematosus (SLE), including hypotheses concerning the induction of SLE by viral infections through molecular mimicry, epitope spreading, activation of T cells by microbial superantigens, bystander activation, and activation of lymphocytes by lymphotropic viruses. During the past decade, many viruses have been brought up in the pathogenesis of SLE. However, HAV has not yet been mentioned as the etiology of SLE. Here, we report a patient tested anti-HAV IgM positive without clinical symptoms of acute hepatitis when diagnosed with new-onset SLE. Because SLE is an immune system disorder, we should take into consideration a variety of etiologies in diagnosis.