A Case of Patient with Lung Adenocarcinoma with Double Rare EGFR Mutation of G719C and L861Q

Other Titles
A Case of Patient with Lung Adenocarcinoma with Double Rare EGFR Mutation of G719C and L861Q
Authors
Jin Tak YunGi Jun KimShin Young KimJoon Won JeongSuk Young ParkYoung Jun YangJi Chan Park
Issue Date
2014
Citation
Keimyung Medical Journal, Vol.33(2) : 132-135, 2014
Abstract
The vast majority of epidermal growth factor receptor (EGFR) gene mutations are detected in lung adenocarcinoma. EGFR mutations are the strongest predictor of response to EGFR tyrosine kinase inhibitor (TKI) treatment in patient with advanced non-small cell lung cancer. Of these, exon 19 deletions and exon 21 L858R point mutations account for more than 80% of mutations detected in tumor with EGFR mutations, which called classical EGFR mutations, and double mutations mainly composed of classical and uncommon EGFR mutations are reported to be present in 13% of total EGFR mutations. But there has been no report to date of patient with double mutation of TKI sensitive uncommon EGFR mutations (G719C and L861Q). We experienced a case of patient with lung adenocarcinoma with double mutation of G719C and L861Q, the first case on our literature review, and showing partial response to TKI treatment.
Keywords
AdenocarcinomaEGFR tyrosine kinase inhibitorLung cancerMutation
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/15643
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2014
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