분만 유도를 위한 경구용과 경질용 Misoprostol의 비교

Abstract

Recently, some studies reported that transvaginal misoprostol induced successful vaginal delivery. The aim of this study were to compare the efficacy and the safety between oral and vaginal administration of misoprostol for the induction of labor. Pregnant women who were hospitalized for the induction of labor from January 2004 to December 2006 at the Dong san Medical Center were included for the prospective randomized study. Subjects as a change in Bishop score of ≥3, Bishop score of ≥6 at 12 hours, or vaginal delivery after the insert placement. One hundred seventy-one women (Oral misoprostol group 85 women / Vaginal misoprostol group 86 women) completed the protocol. There were no statistically significant differences between the two groups in terms of a successful outcome (61.2% vs 67.4%; p=0.223) and the following mean time to vaginal delivery (13.3 hours vs 14.5 hours ; p=0.722). In addition, no differences were observed in the incidences of cesarean delivery, hyperstimulation syndrome, abnormal fetal heart tate patterns, and adverse neonatal outcomes. We concluded that both misoprostol administration routes were equally effective in achieving cervical ripening initiating labor, and achieving a successful vaginal delivery.